Krzysztof Bartus
John Paul II Hospital, Poland
Title: Left atrial appendage occlusion with LARIAT for stroke prevention and neuro-hormonal regulation in patients with atrial fibrillation
Biography
Biography: Krzysztof Bartus
Abstract
Left atrial appendage occlusion with LARIAT for stroke prevention and neuro-hormonal regulation in patients with atrial fibrillation.
Krzysztof Bartus
Jagiellonian University Medical College, Poland
Abstract:
Patients with atrial fibrillation present a significantly increased risk for stroke.
Aim: Evaluate the efficacy of the Left Atrial Appendage Closure (LAAC) in patients with atrial fibrillation and its impact on neuro-hormonal regulation.
Methods: This prospective study enrolled 42 patients, following LAAC with LARIAT device. Following hormone levels were recorded before and after LAAC: adrenaline, noradrenaline, aldosterone, renin, adiponectin, free fatty acids, insulin, ANP and BNP. Follow up at 3 and 6 months. Part of the data published is result of the research grant No. UMO-2015/17/B/NZ5/00125 funded by the National Science Centre Poland.
Results: The amount of stroke and thromboembolic events was 0%, severe bleeding 0%, 1 patient died in the follow up. There were no leaks noted. Significant increases in adiponectin and insulin with decrease in free fatty acids were noted. ANP and BNP were significantly decreased in the acute phase after Lariat which normalized at 3 months. There was a significant decrease in renine, aldosterone, adrenaline and noradrenaline levels at 3 and 6 months.
Conclusion: Lariat procedure is safe and very effective. Significant differences in neuro-hormonal levels were noted. Further studies are required to elucidate the mechanism of hormonal changes.